Medicinal chemistry approaches to personalized medicine / (Record no. 20996)

MARC details
000 -LEADER
fixed length control field 05295cam a2200733Ia 4500
001 - CONTROL NUMBER
control field ocn864744144
003 - CONTROL NUMBER IDENTIFIER
control field OCoLC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20230823095531.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION
fixed length control field m o d
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr cnu---unuuu
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 131206s2014 gw ob 001 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency IDEBK
Language of cataloging eng
Description conventions pn
Transcribing agency IDEBK
Modifying agency EBLCP
-- DG1
-- N$T
-- YDXCP
-- OCLCF
-- OCLCQ
-- DEBSZ
-- COO
-- DEBBG
-- OCLCQ
-- CDX
019 ## -
-- 870511683
-- 961643563
-- 962637366
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783527677283
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 3527677283
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783527677252
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 3527677259
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 1306168902
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9781306168908
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783527333943
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 3527333940
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783527677269
Qualifying information (Mobi)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 3527677267
Qualifying information (Mobi)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783527677276
Qualifying information (ePub)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 3527677275
Qualifying information (ePub)
029 1# - (OCLC)
OCLC library identifier DEBBG
System control number BV043396386
029 1# - (OCLC)
OCLC library identifier DEBSZ
System control number 43157054X
029 1# - (OCLC)
OCLC library identifier NZ1
System control number 15495746
029 1# - (OCLC)
OCLC library identifier NZ1
System control number 15905579
035 ## - SYSTEM CONTROL NUMBER
System control number (OCoLC)864744144
Canceled/invalid control number (OCoLC)870511683
-- (OCoLC)961643563
-- (OCoLC)962637366
037 ## - SOURCE OF ACQUISITION
Stock number 548141
Source of stock number/acquisition MIL
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RS403
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RM111
Item number .L384 2013
060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER
Classification number QV 744
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED
Subject category code subdivision 071000
Source bisacsh
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 615.1/9
Edition number 23
049 ## - LOCAL HOLDINGS (OCLC)
Holding library MAIN
245 00 - TITLE STATEMENT
Title Medicinal chemistry approaches to personalized medicine /
Statement of responsibility, etc edited by Karen Lackey and Bruce D. Roth.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc Weinheim :
Name of publisher, distributor, etc Wiley-VCH,
Date of publication, distribution, etc 2014.
300 ## - PHYSICAL DESCRIPTION
Extent 1 online resource.
336 ## -
-- text
-- txt
-- rdacontent
337 ## -
-- computer
-- c
-- rdamedia
338 ## -
-- online resource
-- cr
-- rdacarrier
490 1# - SERIES STATEMENT
Series statement Medicinal chemistry ;
Volume number/sequential designation Volume 59
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc Includes bibliographical references and index.
588 0# -
-- Print version record.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Methods and Principles in Medicinal Chemistry; Title Page; Copyright; List of Contributors; Foreword; Preface; A Personal Foreword; Acronyms; Chapter 1: Medicinal Chemistry Approaches to Creating Targeted Medicines; 1.1 Introduction; 1.2 Role of Medicinal Chemistry in Drug Discovery; 1.3 Evolution of Molecular Design for Subsets of Patients; 1.4 Combinations for Effective Therapies; 1.5 Biomarkers in Targeting Patients; 1.6 Emerging Field of Epigenetics; 1.7 Systems Chemical Biology; 1.8 Theranostics and Designing Drug Delivery Systems
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 1.9 Rapid Progress in Further Personalizing Medicine ExpectedReferences; Chapter 2: Discovery of Predictive Biomarkers for Anticancer Drugs; 2.1 Introduction; 2.2 "Oncogene Addiction" as a Paradigm for Clinical Implementation of Predictive Biomarkers; 2.3 Cancer Cell Lines as a Model System for Discovery of Predictive Biomarkers; 2.4 Modeling Drug Resistance to Discover Predictive Biomarkers; 2.5 Discovery of Predictive Biomarkers in the Context of Treatment Combinations; 2.6 Discovery of Predictive Biomarkers for Antiangiogenic Agents; 2.7 Gene Expression Signatures as Predictive Biomarkers
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 2.8 Current Challenges in Discovering Predictive Biomarkers2.9 Future Perspective; References; Chapter 3: Crizotinib; 3.1 Introduction; 3.2 Discovery of Crizotinib ( PF -02341066) [40]; 3.3 Kinase Selectivity of Crizotinib; 3.4 Pharmacology of Crizotinib [45,46]; 3.5 Human Clinical Efficacies of Crizotinib; 3.6 Summary; References; Chapter 4: Discovery and Development of Vemurafenib: First-in-Class Inhibitor of Mutant BRAF for the Treatment of Cancer; 4.1 Background; 4.2 Discovery and Development of Vemurafenib (PLX4032); 4.3 Pharmacology; 4.4 Clinical Efficacy and Safety
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 4.5 Companion Diagnostic (cobas 4800) Development4.6 Synthesis; 4.7 Summary; References; Chapter 5: Targeting Basal-Cell Carcinoma: Discovery and Development of Vismodegib ( GDC -0449), a First-in-Class Inhibitor of the Hedgehog Pathway; 5.1 Introduction; 5.2 Hedgehog and Basal-Cell Carcinoma; 5.3 Cyclopamine as an SMO Antagonist; 5.4 Small-Molecule Inhibitors of SMO; 5.5 Preclinical Characterization of Vismodegib; 5.6 Vismodegib Clinical Experience in Phase I; References; Chapter 6: G-Quadruplexes as Therapeutic Targets in Cancer; 6.1 Introduction; 6.2 Quadruplex Fundamentals
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 6.3 Genomic Quadruplexes6.4 Quadruplexes in Human Telomeres; 6.5 Quadruplexes as Anticancer Targets -- Evidence from In Vivo Studies; 6.6 Native Quadruplex Structures; 6.7 Quadruplex-Small-Molecule Structures; 6.8 Developing Superior Quadruplex-Binding Ligands; 6.9 Conclusions; References; Chapter 7: Identifying Actionable Targets in Cancer Patients; 7.1 Introduction and Background; 7.2 Overview of Genomic Sequencing and Its Impact on the Identification of Actionable Mutations; 7.3 Actionable Targets by Clinical Molecular Profiling: the OICR / PMH Experience
526 ## - STUDY PROGRAM INFORMATION NOTE
Department Life Sciences
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Pharmaceutical chemistry.
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element MEDICAL
General subdivision Pharmacology.
Source of heading or term bisacsh
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Pharmaceutical chemistry.
Source of heading or term fast
-- (OCoLC)fst01060115
655 #4 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
655 #0 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lackey, Karen.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Roth, Bruce D.
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Print version:
Title Medicinal chemistry approaches to personalized medicine.
Place, publisher, and date of publication Weinheim : Wiley-VCH, 2014
International Standard Book Number 9783527677252
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title Medicinal chemistry ;
Volume number/sequential designation Volume 59.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1002/9783527677252">http://dx.doi.org/10.1002/9783527677252</a>
Public note Wiley Online Library
994 ## -
-- 92
-- DG1

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