Includes bibliographical references and index.

"This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products. Applies analytical techniques to natural products research - an area of critical importance to drug discovery Offers a one-stop shop for most analytical methods: X-ray diffraction, NMR analysis, mass spectrometry, and chemical genetics Includes coverage of natural products basics and highlights antibacterial research, particularly important as efforts to combat drug resistance gain prominence Covers instrumental techniques with enough detail for both current practitioners and beginning researchers"-- Provided by publisher.

"This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products"-- Provided by publisher.

Print version record and CIP data provided by publisher.

Text in English.

Natural Products Analysis: Instrumentation, Methods,and Applications; Copyright; Contents; Preface; Contributors; Chapter 1 Natural Products Analysis: Instrumentation, Methods, and Applications; 1.1 Book Motivation; 1.2 The Broad Field of Natural Products; 1.3 Discovery Phases; 1.4 Absolute Structure; 1.5 Mass Spectral Applications in Concert; 1.6 Complex Structures and Complex Mixtures; References; Chapter 2 The Need for New Antifungal and Antimalarial Compounds; 2.1 Introduction; 2.2 Fungal Infections; 2.2.1 Fungal Diseases; 2.2.2 Antifungal Therapy; 2.2.3 Fluoropyrimidines; 2.2.4 Azoles

2.2.5 Echinocandins2.2.6 Other Peptides; 2.2.7 Polyenes; 2.2.8 Miscellaneous Antifungals; 2.3 Malaria; 2.3.1 The Disease; 2.3.2 Quinine; 2.3.3 Artemisinin; 2.3.4 Tetracyclines; 2.3.5 Clindamycin; 2.3.6 Combinations of Drugs; 2.4 Conclusions; References; Chapter 3 Emerging Instrumental Methods for Antimicrobial Resistance and Virulence Testing; 3.1 Introduction; 3.2 Mass Spectrometry; 3.3 Nucleic Acid Amplification and Sequencing; 3.4 Perspective; Acknowledgment; References; Chapter 4 Plant and Marine Sources: Biological Activity of Natural Products and Therapeutic Use; 4.1 Introduction

4.2 Significance of Plant Sources4.2.1 Methods Used in Chemistry of Plant-Derived Products; 4.2.2 Chemistry and the Modes of Action of Plant Metabolites; 4.3 Impact of Marine Natural Products; 4.3.1 Marine Chemical Biology; 4.4 Natural Products and Diseases; 4.4.1 Endocrine System-Diabetes; 4.4.2 Cardiovascular Ailments; 4.4.3 Antiplatelet and Antisclerotic Drugs; 4.4.4 Diseases Correlated with Problems of the Central Nervous System (CNS); 4.4.5 Plants Used Against the Respiratory Disorders; 4.4.6 Infectious Diseases and the Use of Plant- or Marine-Derived Drugs

4.4.7 Anticancer Drugs from Plants and Marine Sources4.5 Conclusions; References; Chapter 5 Emerging Trends for Stimulating the Discovery of Natural Products; 5.1 Mass Spectrometry-Based Metabolomics; 5.2 Metagenomics and Symbiosis; 5.3 Bioinformatic Annotation of Biosynthetic Pathways and Structure Prediction; 5.4 New Tools For Absolute Configuration Determination; References; Chapter 6 Advances and Challenges in Optical Molecular Spectroscopy Including Surface Plasmon Resonance-Based Methods for Bioanalysis; 6.1 Introduction to Principles and Analytical Aspects of Optical Spectroscopy

6.1.1 Description of Electromagnetic Radiation and Its Propagation6.1.2 Light Absorption and the Beer-Lambert-Bouguer Law; 6.1.3 Deviations from the Beer-Lambert-Bouguer Law; 6.1.4 Calibration Methods in Optical Spectroscopy; 6.1.5 Multivariate Quantitative Models; 6.1.6 Multivariate Classification Models; 6.2 Molecular Spectroscopy and Its Instrumentation; 6.2.1 Types of Molecular Optical Spectroscopic Methods; 6.2.2 General Types of Instrumentation; 6.2.3 Electronic States and Electronic Spectroscopy; 6.2.4 Vibrational States and Methods of Vibrational Spectroscopy

microbiology