TY - BOOK AU - Crawley,Matthew L. AU - Trost,Barry M. TI - Applications of transition metal catalysis in drug discovery and development: an industrial perspective SN - 9781118309872 AV - QV744 U1 - 615.1/9 23 PY - 2012/// CY - Hoboken, N.J. PB - John Wiley & Sons KW - Catalysis KW - Transition metals KW - Pharmacy KW - Drug Discovery KW - Pharmaceutical Preparations KW - chemistry KW - Transition Elements KW - Medicine KW - MEDICAL KW - Drug Guides KW - bisacsh KW - Nursing KW - Pharmacology KW - fast KW - Electronic books KW - local N1 - Includes bibliographical references and index; Applications of TRANSITION METAL CATALYSIS in Drug Discovery and Development; Contents; Preface; Contributors; About the Authors; 1 Transition Metal Catalysis in the Pharmaceutical Industry; 1.1 Overview of Catalysis; 1.2 Transition Metal Catalysis in the Pharmaceutical Industry; 1.2.1 Cross-Couplings for the Formation of Carbon-Carbon Bonds; 1.2.2 Cross-Couplings for the Formation of Carbon-Heteroatom Bonds; 1.2.3 Asymmetric Hydrogenation; 1.2.4 Oxidative Catalysis; 1.2.5 Asymmetric Addition Reactions; 1.2.6 Metathesis; 1.3 Challenges in Taking Catalysis to Industrial Scales; phr N2 - "This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development."--Provided by publisher UR - http://dx.doi.org/10.1002/9781118309872 ER -