Print version record.

Vitamin A Metabolic and Enzymatic Pathways. Vitamin A Metabolism, Storage and Tissue Delivery Mechanisms / William S Blaner, Yang Li -- Assimilation and Conversion of Dietary Vitamin A into Bioactive Retinoids / Earl H Harrison, Carlo dela Sena's -- Intracellular Storage and Metabolic Activation of Retinoids / Joseph L Napoli, Charles R Krois -- Evolution of the Retinoic Acid Signaling Pathway / Vincent Laudet, Elisabeth Zieger, Michael Schubert -- Biochemistry and Cellular Biology of Retinoic Acid Signaling. Control of Gene Expression by Nuclear Retinoic Acid Receptors / Marilyn Carrier, Cecile Rochette-Egly -- Retinoic Acid Receptor Coregulators in Epigenetic Regulation of Target Genes / Li-Na Wei -- Retinoid Receptors / William Bourguet, Dino Moras -- How the RAR-RXR Heterodimer Recognizes the Genome / Sylvia Urban, Tao Ye, Irwin Davidson -- Retinoid Receptor-Selective Modulators / Marco-Antonio Mendoza-Parra, William Bourguet, Angel R de Lera, Hinrich Gronemeyer -- Use of Retinoid Receptor Ligands to Identify Other Nuclear Receptor Ligands / Marcia I Dawson, Zebin Xia -- The Dual Transcriptional Activity of Retinoic Acid / Noa Noy -- Retinoids, Epigenetic Changes during Stem Cell Differentiation, and Cell Lineage Choice / Lorraine J Gudas -- Retinoic Acid Signaling in Development. Retinoic Acid Signaling and Central Nervous System Development / Malcolm Maden -- The Role of Retinoic Acid in Limb Development / Gregg Duester -- Retinoic Acid Signaling and Heart Development / Stephane Zaffran, Karen Niederreither -- Retinoic Acid in the Developing Lung and Other Foregut Derivatives / Wellington V Cardoso, Felicia Chen -- Retinoic Acid and the Control of Meiotic Initiation / Josephine Bowles, Peter Koopman -- Retinoids and Physiological Functions. Retinoids and the Visual Cycle / Darwin Babino, Johannes von Lintig -- Retinoid Signaling in the Central Nervous System / Peter McCaffery, Wojciech Krezel -- Retinoid Turnover and Catabolism / A Catharine Ross, Reza Zolfaghari -- Retinoids and the Immune System / J Rodrigo Mora, Makoto Iwata -- Retinoic Acid Receptor Signaling in Post-Natal Male Germ Cell Differentiation / Manuel Mark, Norbert B Ghyselinck -- Retinoids, Disease and Therapy. Epidemiology and Prevention of Vitamin A Deficiency Disorders / Keith P West -- Retinoid Pathway Gene Mutations and the Pathophysiology of Related Visual Diseases / Yaroslav Tsybovsky, Krzysztof Palczewski -- Retinoic Acid in Acute Myeloid Leukemias / Hugues de The, Pierre Fenaux -- Advances in the Use of Retinoids in Cancer Therapy and Prevention / Michael J Spinella, Sarah J Freemantle, Ethan Dmitrovsky.

Includes index.

The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. The book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five parts, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy.

Includes bibliographical references at the end of each chapters and index.

Life Sciences