000			04704cam a2200589Ma 4500
001			ocn802056669
003			OCoLC
005			20230823095528.0
006			m o d
007			cr cn|||||||||
008			120713s2012 gw a ob 001 0 eng d
040			_aE7B _beng _epn _cE7B _dOCLCO _dCDX _dDG1 _dYDXCP _dOCLCQ _dMMU _dOCLCF _dCOO _dOCLCQ _dDEBBG _dAZK
019			_a961632173 _a962650062
020			_a9783527652969 _q(electronic bk.)
020			_a3527652965 _q(electronic bk.)
020			_a9783527652938 _q(e-book)
020			_a3527652930 _q(e-book)
020			_z9783527330591
029	1		_aAU@ _b000050060714
029	1		_aDKDLA _b820120-katalog:000599741
029	1		_aNZ1 _b14793349
029	1		_aDEBBG _bBV043394927
035			_a(OCoLC)802056669 _z(OCoLC)961632173 _z(OCoLC)962650062
050		4	_aRC119.7 _b.P37 2012eb
082	0	4	_a616.96061 _223
049			_aMAIN
245	0	0	_aParasitic helminths : _btargets, screens, drugs and vaccines / _cedited by Conor R. Caffrey.
260			_aWeinheim, Germany : _bWiley-VCH, _c2012.
300			_a1 online resource (xxiii, 516 pages :) : _billustrations (some color).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_adata file _2rda
380			_aBibliography
490	1		_aDrug discovery in infectious diseases ; _vv. 3
504			_aIncludes bibliographical references and index.
505	0		_aPart one: targets -- Ligand-gated ion channels as targets for anthelmintic drugs: past, current, and future perspectives -- How relevant is Caenorhabditis elegans as a model for the analysis of parasitic nematode biology? -- Integrating and mining helminth genomes to discover and prioritize novel therapeutic targets -- Recent progress in transcriptomics of key gastrointestinal nematodes of animals: fundamental research toward new intervention strategies -- Harnessing genomic technologies to explore the molecular biology of liver flukes-major implications for fundamental and applied research -- RNA interference: a potential discovery tool for therapeutic targets of parasitic nematodes -- RNA interference as a tool for drug discovery in parasitic flatworms -- Part two: screens -- Mechanism-based screening strategies for anthelmintic discovery -- Identification and profiling of nematicidal compounds in veterinary parasitology -- Quantitative high-content screening-based drug discovery against helmintic diseases -- Use of rodent models in the discovery of novel anthelmintics -- To kill a mocking worm: strategies to improve Caenorhabditis elegans as a model system for use in anthelmintic discovery -- Part three: drugs -- Anthelmintic drugs: tools and shortcuts for the long road from discovery to product -- Antinematodal drugs: modes of action and resistance: and worms will not come to thee (Shakespeare: Cymbeline: iv, ii) -- Drugs and targets to perturb the symbiosis of Wolbachia and filarial nematodes -- Promise of Bacillus thuringiensis crystal proteins as anthelmintics -- Monepantel: from discovery to mode of action -- Discovery, mode of action, and commercialization of derquantel -- Praziquantel: too good to be replaced? -- Drug discovery for trematodiases: challenges and progress -- Part four: vaccines -- Barefoot thru' the valley of darkness: preclinical development of a human hookworm vaccine -- Vaccines linked to chemotherapy: a new approach to control helminth infections -- Antifilarial vaccine development: present and future approaches -- Proteases as vaccines against gastrointestinal nematode parasites of sheep and cattle -- Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates -- Sm14 Schistosoma mansoni fatty acid-binding protein: molecular basis for an antihelminth vaccine -- Mechanisms of immune modulation by Fasciola hepatica: importance for vaccine development and for novel immunotherapeutics -- Prospects for immunoprophylaxis against Fasciola hepatica (liver fluke) -- Vaccines against cestode parasites.
650		0	_aHelminths.
650		0	_aParasites.
650		0	_aParasitic diseases _xTreatment.
650		0	_aParasitic diseases _xDiagnosis.
650		7	_aHelminths. _2fast _0(OCoLC)fst00954813
650		7	_aParasites. _2fast _0(OCoLC)fst01053134
650		7	_aParasitic diseases _xDiagnosis. _2fast _0(OCoLC)fst01053153
650		7	_aParasitic diseases _xTreatment. _2fast _0(OCoLC)fst01053167
655		4	_aElectronic books.
700	1		_aCaffrey, Conor R.
830		0	_aDrug discovery in infectious diseases ; _vv. 3.
856	4	0	_uhttp://dx.doi.org/10.1002/9783527652969 _zWiley Online Library
994			_a92 _bDG1
999			_c19649 _d19608
526			_bls