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008 130629s2013 iau ob 001 0 eng d
040 _aEBLCP
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019 _a868940046
020 _a9781118453902
_q(electronic bk.)
020 _a1118453905
_q(electronic bk.)
020 _a9781118453926
_q(electronic bk.)
020 _a1118453921
_q(electronic bk.)
020 _a1118453883
_q(softback ;
_qalk. paper)
020 _a9781118453889
_q(softback ;
_qalk. paper)
020 _a9781118453896
_q(eMobi)
020 _a1118453891
_q(eMobi)
020 _a9781118453919
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020 _a1118453913
_q(ePub)
020 _z9781118453889
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029 1 _aDKDLA
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029 1 _aGBVCP
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029 1 _aNZ1
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035 _a(OCoLC)851315970
_z(OCoLC)868940046
050 4 _aRC931.M45
072 7 _aHEA
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072 7 _aMED
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072 7 _aMED
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082 0 4 _a616.7/16
_a616.716
_222
049 _aMAIN
245 0 0 _aPrimer on the metabolic bone diseases and disorders of mineral metabolism /
_ceditor-in-chief, Clifford J. Rosen ; senior associate editors, Roger Bouillon, Juliet E. Compston, Vicki Rosen ; associate editors, Douglas P. Bauer [and others].
250 _a8th ed.
260 _aAmes, Iowa :
_bWiley-Blackwell,
_c2013.
300 _a1 online resource (xxvi, 1078 pages)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
505 0 _aCover; Title page; Copyright page; Contents; Contributors; Primer Corporate Sponsors; Preface to the Eighth Edition of the Primer; About ASBMR; President's Preface; About the Companion Website; Section I: Molecular Cellular and Genetic Determinants of Bone Structure and Formation; 1: Skeletal Morphogenesis and Embryonic Development; Early Skeletal Patterning; Craniofacial patterning; Axial patterning; Limb patterning; Embryonic Cartilage and Bone Formation; Chondrocyte Proliferation and Differentiation in The Developing Cartilage; Regulation of Chondrocyte Survival; Conclusions; References.
505 8 _a2: Signal Transduction Cascades Controlling Osteoblast Differentiation; Introduction; Runx2 and Osterix Transcription Factors; BMP Signaling; TGF-ß Signaling; WNT Signaling; Hedgehog Signaling; PTH Signaling; IGF-1 Signaling; FGF Signaling; Notch Signaling; Concluding Remarks; Acknowledgments; References; 3: Osteoclast Biology and Bone Resorption; Cell Biology of The Osteoclast; Integrin Signaling; Small GTPases; Factors Regulating Osteoclast Formation And/Or Function; Proteins; Small molecules; Cell-Cell Interactions in Bone Marrow; Intracellular Signaling Pathways; Human Genetics; References.
505 8 _a4: Osteocytes; Introduction; Osteocyte Ontogeny; Osteocytes as Orchestrators of Bone (Re)Modeling; Osteocyte Cell Death and Apoptosis; Osteocyte Modification of Their Microenvironment; Mechanosensation and Transduction; Role of Gap Junctions and Hemichannels in Osteocyte Communication; The Potential Role of Osteocytes in Bone Disease; Acknowledgment; References; 5: Connective Tissue Pathways That Regulate Growth Factors; Introduction; The Fibrillinopathies; Fibrillin Microfibrils; Regulation of Growth Factors by Fibrillin Microfibrils; Molecular Mechanisms Orchestrated on a Microfibril Scaffold.
505 8 _aAbbreviations; References; 6: The Composition of Bone; Introduction; The Composite; The mineral; Collagen; Noncollagenous Proteins; Serum-derived proteins; Proteoglycans; Glycosylated proteins; Small integrin-binding ligand, N-glycosylated protein, and other glycoproteins with cell attachment activity; Gla-containing proteins; Other Components; References; 7: Assessment of Bone Mass and Microarchitecture in Rodents; Introduction; Radiographs; Peripheral Dual-Energy X-Ray Absorptiometry; Peripheral Quantitative Computed Tomography; Magnetic Resonance Imaging; Microcomputed Tomography.
505 8 _aNanocomputed Tomography; Imaging Considerations; Voxel size and image resolution; Segmentation; Skeletal site and volume of interest; Calibration; Other considerations; Conclusions; References; 8: Animal Models: Genetic Manipulation; Introduction; Overexpression of Target Genes; Chondrocytes; Osteoblasts; Tendon and ligament; Osteoclasts; Advantages and disadvantages of overexpression approaches; Gene Targeting; Advantages and disadvantages of gene targeting; Tissue-Specific and Inducible Knockout and Overexpression; Uncondensed mesenchyme, mesenchymal condensations, and neural crest; Cartilage; Osteoblasts.
520 _aPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions.
588 0 _aPrint version record.
504 _aIncludes bibliographical references at the end of each chapters and index.
650 0 _aBones
_xMetabolism
_xDisorders.
650 0 _aMineral metabolism
_xDisorders.
650 0 _aBones
_xDiseases.
650 2 _aBone Diseases, Metabolic.
650 2 _aBone and Bones
_xmetabolism.
650 2 _aMinerals
_xmetabolism.
650 7 _aHEALTH & FITNESS
_xDiseases
_xMusculoskeletal.
_2bisacsh
650 7 _aMEDICAL
_xOrthopedics.
_2bisacsh
650 7 _aMEDICAL
_xRheumatology.
_2bisacsh
650 7 _aBones
_xDiseases.
_2fast
_0(OCoLC)fst00836004
650 7 _aBones
_xMetabolism
_xDisorders.
_2fast
_0(OCoLC)fst00836025
650 7 _aMineral metabolism
_xDisorders.
_2fast
_0(OCoLC)fst01022354
655 4 _aElectronic books.
700 1 _aRosen, Clifford J.
700 1 _aBouillon, R.
700 1 _aCompston, Juliet.
700 1 _aRosen, Vicki.
776 0 8 _iPrint version:
_tPrimer on the metabolic bone diseases and disorders of mineral metabolism.
_b8th ed.
_dAmes, Iowa : Wiley-Blackwell, 2013
_z9781118453889
_w(DLC) 2013002831
_w(OCoLC)826287961
856 4 0 _uhttp://dx.doi.org/10.1002/9781118453926
_zWiley Online Library
994 _a92
_bDG1
999 _c20673
_d20632
526 _bls