000			05858cam a2200589Ia 4500
001			ocn716174431
003			OCoLC
005			20220701010949.0
006			m o d
007			cr cn|||||||||
008			110428s2011 enk o 001 0 eng d
040			_aUIU _beng _epn _cUIU _dDG1 _dYDXCP _dOCLCQ _dIDEBK _dOCLCQ _dOCLCA _dSTF _dOCLCA _dOCLCF _dOCLCO _dNLGGC _dDEBBG _dOCLCQ
019			_a711782138 _a772397964 _a816879083
020			_a9780470979624 _q(electronic bk.)
020			_a0470979623 _q(electronic bk.)
020			_a1283374056
020			_a9781283374057
029	1		_aAU@ _b000047158761
029	1		_aDEBBG _bBV041900813
029	1		_aGBVCP _b790033127
029	1		_aNZ1 _b15900651
035			_a(OCoLC)716174431 _z(OCoLC)711782138 _z(OCoLC)772397964 _z(OCoLC)816879083
037			_a10.1002/9780470979624 _bWiley InterScience _nhttp://www3.interscience.wiley.com
050		4	_aQP363.5 _b.B85 2011
060		4	_aWL 102.5
072		7	_aPS _2bicssc
082	0	4	_a612.8 _222
049			_aMAIN
245	0	0	_aBuilding brains : _ban introduction to neural development / _cDavid Price [and others].
260			_aChichester, UK : _bJohn Wiley & Sons, _c2011.
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
505	0		_aFront Matter -- Models and Methods for Studying Neural Development -- The Anatomy of Developing Nervous Systems -- Neural Induction: An Example of How Intercellular Signalling Determines Cell Fates -- Patterning the Neuroectoderm -- Neurogenesis: Generating Neural Cells -- Neuronal Migration -- How Neurons Develop Their Shapes -- Axon Guidance -- Map Formation -- Maturation of Functional Properties -- Life and Death in the Developing Nervous System -- Experience-Dependent Development -- Suggestions for Further Reading -- Glossary -- Index.
505	0		_aModels and methods for studying neural development -- The anatomy of developing nervous systems -- Neural induction : an early example of how intercellular signalling determines cell fates -- Patterning the neuroectoderm -- Neurogenesis : generating neural cells -- Neuronal migration -- How neurons develop their shapes -- Axon pathfinding : the long and winding road -- Map formation -- Maturation of functional properties -- Life and death in the developing nervous system -- Experience-dependent development.
588	0		_aPrint version record.
520			_aThe development of a brain from its simple beginnings in the embryo to the extraordinarily complex fully-functional adult structure is a truly remarkable process. Understanding how it occurs remains a formidable challenge despite enormous advances over the last century and current intense world-wide scientific research. A greater knowledge of how nervous systems construct themselves will bring huge benefits for human health and future technologies. Unravelling the mechanisms that lead to the development of healthy brains should help scientists tackle currently incurable diseases of the nervous system such as autism, epilepsy and schizophrenia (to name but a few), discover more about the processes that cause the uncontrolled growth associated with cancer and develop possible treatments. Building Brains provides a highly visual and readily accessible introduction to the main events that occur during neural development and the mechanisms by which they occur. Aimed at undergraduate students and postgraduates new to the field, who may not have a background in neuroscience and/or molecular genetics, it explains how cells in the early embryo first become neural, how their proliferation is controlled, what regulates the types of neural cells they become, how neurons connect to each other, how these connections are later refined under the influence of neural activity including that arising from experience, and why some neurons normally die. Key Features: A concise illustrated guide focusing on the core elements of current understanding of neural development, emphasising common principles underlying developmental mechanisms and supplemented by suggestions for further reading. Text boxes throughout provide further detail on selected major advances, issues of particular uncertainty or controversy and examples of human diseases that result from abnormal development. A balanced mammalian/non-mammalian perspective, drawing on examples from model organisms including the fruit fly, nematode worm, frog, zebrafish, chick, mouse, ferret, cat, monkey and human, and emphasising mechanisms that are conserved across species. Introduces the methods for studying neural development including genetics, transgenic technologies, advanced microscopy and computational modeling, allowing the reader to understand the main evidence underlying research advances. Student-friendly, full colour artwork reinforces important concepts; an extensive glossary and definitions in page margins help readers from different backgrounds; chapter summaries stress important points and aid revision. Associated Website includes a complete set of figures from the textbook.
650		0	_aDevelopmental neurobiology.
650		0	_aNervous system _xGrowth.
650		2	_aNeurons _xphysiology.
650		2	_aNervous System _xanatomy & histology.
650		2	_aNeurogenesis.
650		7	_aDevelopmental neurobiology. _2fast _0(OCoLC)fst00891810
650		7	_aNervous system _xGrowth. _2fast _0(OCoLC)fst01036128
655		4	_aElectronic books.
700	1		_aPrice, David J., _d1957 November 20-
710	2		_aWiley InterScience (Online service)
776	0	8	_iPrint version: _tBuilding brains. _dChichester, UK : John Wiley & Sons, 2011 _z9780470712306 _w(DLC) 2010053724 _w(OCoLC)694600455
856	4	0	_uhttp://dx.doi.org/10.1002/9780470979624 _zWiley Online Library
994			_a92 _bDG1
999			_c21534 _d21493