000			03728nam\a2200301\a\4500
001			47318
005			20231128095712.0
008			230712s2008 nyua bf 001 0 eng
020			_a0824705629 (alk. paper)
040			_aDLC _cDLC _dBD- DhIUB
082	0	0	_a615.19 _223 _bH2361
245	0	0	_aHandbook of drug screening / _cedited by Ramakrishna Seethala, Prabhavathi B. Fernandes.
260			_aNew York : _bMarcel Dekker, _cc2001.
300			_axiii, 597 p. : _bill. ; _c24 cm.
440		0	_aDrugs and the pharmaceutical sciences ; _vv. 114
504			_aIncludes bibliographical references and index.
505	8		_aMachine generated contents note: 1. Moving Into the Third Millennium After a Century of -- Screening -- Prabhavathi B. Ferandes -- 2. Basic Considerations in Designing High-Throughput Screening -- Assays -- Duane Bronson, Nathaniel Hentz, William P. Janzen, Mark D. -- Lister, Karl Menke, Jeffrey Wegrzyn, and G. Sitta Sittampalam -- 3 Screening Platforms -- Ramakrishna Seethala -- Homogeneous Assays for High-Throughput and Ultrahigh- -- Throughput Screening -- Ramakrishna Seethala -- Microbe-Based Screening Systems -- 'rabhavathi B. Ferandes -- 6. Molecular Genetic Screen Design for Agricultural and -- Pharmaceutical Product Discovery 152 -- Donald R. Kirsch, William Baumbach, Julia N. Heinrich, -- Margaret Lai, Mark H. Pausch, Laura Sarokin, Sanford -- Silverman, and James C. Walsh -- 7. Receptor Screens for Small Molecule Agonist and Antagonist -- Discovery 1I -- Ramakrishna Seethala -- 8. Functional Assay Screens 2 -- Maria L. Webb, Robert A. Horlick, Bassam Damaj, and Kirk -- McMillan -- 9. Enzyme Screens -- Thomas D. Y. Chung and Dennis J. Murphy -- 10. Screening Strategies for Ion Channel Targets -- Thomas H. Large and Martin W. Smith -- 11. High-Throughput Screening Assays for Detection of -- Transcription -- Mohanram Sivaraja -- 12. Screening of Combinatorial Biology Libraries for Natural -- Products Discovery -- Christopher J. Silva, Paul Brian, and Todd Peterson -- 13. Higher-Throughput Screening Assays With Human Hepatocytes -- for Hepatotoxicity, Metabolic Stability, and Drug-Drug -- Interaction Potential -- Albert P. Li -- 14. High-Throughput Screening for Metabolism-Based Drug-Drug -- Interactions -- Vaughn P. Miller and Charles L. Crespi -- 15. The ATCG of Drug Discovery -- Prabhavathi B. Fernandes -- 16. Genomics/Functional Proteomics for Ilentification of New -- Targets -- A. Donny Strosberg -- 17. Bioinformatics: Identification of Novel Targets and Their -- Characterization -- Chandra S. Ramanathan -- 18. The Evolution of Laboratory Automation -- Jack Elands -- 19. Robotics and Automation -- Robert F. Trinka and Franz E. Leichtfried -- 20. Assay Miniaturization: Developing Technologies and Assay -- Formats -- Kevin R. Oldenburg, Ilona Kariv, Ji-hu Zhang, Thomas D. Y. -- Chung, and Siqi Lin -- 21. Screening in the NanoWorld: Single-Molecule Spectroscopy and -- Miniaturized High-Throughput Screening -- Rodney Turner, Dirk Ullmann, and Sylvia Sterrer -- Index.
526			_aPHR _beee _lPHAR
650		0	_aDrug development _vHandbooks, manuals, etc.
650		0	_aDrugs _xTesting _vHandbooks, manuals, etc.
700	1		_aSeethala, Ramakrishna, _d1947-
700	1		_aFernandes, P. B. _q(Prabhavathi B.)
856	4	1	_3Table of Contents only
856	4	2	_3Publisher description _uhttp://www.loc.gov/catdir/enhancements/fy0647/2001032412-d.html
856	4	2	_3Book review (E-STREAMS) _uhttp://www.e-streams.com/es0504/es0504_1855.htm
942			_2ddc _cBK
999			_c47318 _d47277